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KMID : 0380620230550020120
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Korean Journal of Food Science and Technology
2023 Volume.55 No. 2 p.120 ~ p.126
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Functional assessment of the combined extracts of Nelumbo nucifera L. and Platycodon grandiflorus on fat accumulation in differentiated 3T3-L1 adipocytes
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Kang Eun-Young
Jeong Jeong-Ho
Kim Ye-Jin
Kim Hyun-Kyung
Kang Su-Min
Kim Ha-Yoon
Jang Ji-Hye
Gang Gyoung-Ok
Lee Sang-Gil
Park Hee-Jung
Go Gwang-Woong
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Abstract
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The continuous increase in obesity necessitates innovative preventive measures. Plant extracts from Diospyros kaki L. (DE), Nelumbo nucifera L. (NE), Rosa canina (RE), Chrysanthemum morifolium (CE), and Platycodon grandiflorus (PE) have been traditionally consumed for medicinal purposes in Asia and Europe. In this study, we evaluated the antiobesity effects of plant extracts. Fat accumulation was inhibited by PE, DE, and NE in a dose-dependent manner. NE was further mixed at ratios of 1:1-1:5 with PE, and a mixture of 300 μg/mL showed no less reduction in cellular fat than 600 μg/mL of the mixture. Representative enzymes related to lipogenesis and thermogenesis were evaluated. FAS was reduced, whereas uncoupling-protein 1 (UCP1) was enhanced in adipocytes up to 300 μg/mL of a mixture. In conclusion, the combined extract of NE and PE (1:5) is a potent nutraceutical with anti-obesity effects.
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KEYWORD
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Nelumbo nucifera L., Platycodon grandiflorus, 3T3-L1, fatty acid synthase, uncoupling protein 1
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